Cell-to-cell infection is achieved through cell–cell fusion, facilitating the direct spread between the cells evading the immune system (Du et al. 2009). The central target receptor on surfaces of human cells is the angiotensin-converting enzyme 2 (ACE2). This homotrimeric S-glycoprotein is ...
The COVID-19 pandemic, caused by the novel SARS-CoV-2 coronavirus, has threatened global public health and is associated in particular with respiratory-related morbidity and mortality. This beta coronavirus SARS-CoV-2 is believed to have originated in Wuhan City in China and then spread world...
CoV-2 Covid-19 Sepsis Acute pancreatitis Aging 1. Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a potentially life-threatening disease, defined as Coronavirus Disease 19 (COVID-19). This pathological condition is generally characterized by the presence of several ...
Neutrophil action is stimulated by the tension of moving erythrocytes, with the speed being in accordance with the speed of red cells [10]. Selectins and their ligands promote the adhesive interaction that causes leukocyte rolling. Selectins are a family of surface molecules of glycoprotein ...
2. ApoB100: Structure, Function, and Metabolism The ApoB100 glycoprotein is composed of 4536 amino acid residues, with a molecular weight exceeding 500,000 Daltons. It possesses several hydrophobic domains that function as lipid-binding areas, along with binding sites for the LDL receptor (LDL-...
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Though a butterfly rash is often considered characteristic of lupus, other conditions that can cause it include rosacea, erysipelas, cellulitis, dermatomyositis, and pellagra.
Furthermore, compared with the BDL rats, TNF-[alpha] (0.5-fold, P < 0.01), IL-1[beta] (0.6-fold, P < 0.05), and TGF-[beta] (0.51-fold, P < 0.01) decreased in the BDL+AICAR rats, and there was a significant decline in CD68 (0.78-fold, P < 0.05), CD40 (0.78-fold, P ...
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Cell entry of SARS-CoV-2 is mediated by the binding of the S protein of the virus to the host angiotensin-2–converting enzyme (ACE-2) [55]. This cellular receptor is a type I membrane glycoprotein responsible for the conversion of angiotensin II into angiotensin 1–7 present on the ...