The first theory concerning tolerance, described by Burnet, Fenner, and Medawar, stated that self-tolerance is achieved by the elimination of autoreactive clones during the differentiation of the immune system.However, the development of autoimmune diseases proved that deletion of these clones was not...
This causes the damage to the body and is known as auto-immune disease. Increased helper T cell and decreased suppressor T cell functions have been suggested as causes of autoimmunity. Examples of autoimmune diseases are rheumatoid arthritis, insulin-dependent diabetes, chronic anaemia, chronic ...
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(b) What main factors contribute to autoimmunity? Immune Response: An immune response is generated by the body's defence mechanism system. It is produced by many subsets of lymphocytes. This is a chemical reaction occurring in our body to protect from pathogens, microbes, bacteria a...
Natural autoantibodies provide immediate protection against infection and also prevent inflammation by facilitating the clearance of oxidized lipids, oxidized proteins, and apoptotic cells; their role in development of autoimmunity is still unclear. Detection of serum autoantibodies in clinical practice has ...
[7]. Xu H, Zhang X, Wang X, et al. Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity. Immunity. 2024;57(8):1796-1811.e8. [8]. Subudhi I, Konieczny P, Prystupa A, et al. Metabolic coordination b...
phenotype association or by pleiotropy [4,6]. In this sense, clinical observations indicate the possible shift from one disease to another, or the fact that more than one AD may coexist in a single patient (that is, polyautoimmunity) or in the same family (that is, familial autoimmunity) ...
The study of sexual dimorphism in psychiatric and neurodevelopmental disorders is challenging due to the complex interplay of diverse biological, psychological, and social factors. Males are more susceptible to neurodevelopmental disorders including inte
In conclusion, data suggest an increased risk of depression and anxiety along with evidence of X-chromosome-associated changes in autoimmunity in KS and TS. In non-syndromic populations, the association between depression and anxiety disorders and the immune system is increasingly described. These stud...
A-B Mongey is Professor of Internal Medicine and Director of the Rheumatology Fellowship Program in the Division of Immunology at the University of Cincinnati, and is also the Medical Director of the Medical Subspeciality and Arthritis Clinics at The University Hospital, Cincinnati, OH., ...