George N. Papanicolaou, to convey a very low suspicion of (pre)malignancy. Despite controversies concerning its ambiguous and imprecise definition and its uncertain optimal use, the term "atypia" has continued to be used in cytopathology, and has recently been increasingly used in standardized non...
with risks for invasive cancer at 10 years in patients with low-grade lesions similar to risks in patients diagnosed with atypia.1The so-called lobular carcinoma in situ is generally considered a marker
Long-standing chronic inflammation with gallstones (over 10–15 years) has also been identified as a potential risk factor for developing atypia, dysplasia, and carcinoma, particularly if there is development of porcelain Conclusion Not only clinically suspicious, but even incidentally detected gall...
What is atypia? Use, misuse and overuse of the term atypia in diagnostic cytopathology The term "atypical" was introduced by the founder of modern cytodiagnosis, Dr. George N. Papanicolaou, to convey a very low suspicion of (pre)malignancy. D... Stefan,E.,Pambuccian - 《Journal of the...
Definition 2 A benign or malignanttissue growthresulting fromuncontrolledcell proliferation. Benignneoplastic cellsresemblenormal cellswithout exhibitingsignificantcytologicatypia, whilemalignant cellsexhibit overt signs such as dysplasticfeatures,atypical mitotic figures,necrosis,nuclear pleomorphism, and anaplasia. ...
S1 Table: histologic diagnosis between the groups of direct thyroidectomy and of thyroidectomy after two or more consecutive FNAs after initially being diagnosed as AUS/FLUS. Malignancy Risk and Related Factors of Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance in Thyroid...
The rate of nuclear atypia, presence of tumor necrosis, and high mitotic activity [mitosis if it is [greater than or equal to]10/high-power field (HPF)] are important criteria for defining malignancy. Diagnostic and Prognostic Significance of p16, p53, and bcl-2 Expressions and Ki-67 Prolif...
With 3%-7% prevalence, it is the second most common subtype. Of the tumor cells, 80% show a clear cell morphology with a light cytoplasm and minor nuclear atypia. The “brightness” of the cells occurs because the tumor cells accumulate glycogen [Figure 6A-C][76-78]. ...
To assess the significance of flat epithelial atypia (FEA) on core biopsy by evaluating the proportion of cases upgraded to in-situ and invasive carcinoma on further sampling with vacuum-assisted biopsy (VAB) or diagnostic surgical biopsy.A retrospective analysis was performed of all core biopsies ...
Aims To assess the significance of flat epithelial atypia (FEA) on core biopsy by evaluating the proportion of cases upgraded to in-situ and invasive carcinoma on further sampling with vacuum-assisted biopsy (VAB) or diagnostic surgical biopsy. Methods A retrospective analysis was performed of all...