Protein hyperfluorescence is of course not always due to enhanced native mobility; true thermodynamic intermediates can hyperfluoresce for the same reasons that a pretransition native state does. A classic example is the I state formed during low pH denaturation of apomyoglobin (Barrick and Baldwin,...
Future House– a new Silicon Valley-based non-profit company in the AI4Science space funded by ex-Google CEO Eric Schmidt. Head of Science is Andrew White, known for his works on LLMs for chemistry. The self-described mission of the company is a "moonshot to build an ...
Long-branch attraction (LBA) artefacts were detected in all the datasets. Methods using Bayesian inference outperformed maximum likelihood approaches, and LBA was avoided in Paraneoptera and Holometabola when using protein sequences and the site-heterogeneous mixture model CAT. The better performance ...
Firstly, exposure to near-future OA scenarios may reduce the total counts and alter the cell-type compositions of hemocytes and coelomocytes, which are regarded as the main immune cells in marine animals (Liu et al., 2016). Secondly, phagocytosis executed by hemocytes, which is the primary...