Fig. 4. RG2 rat glioblastoma cells counterstained with human anti-CRP antibodies. The cells exhibit a distinct binding of the CRP antibody. In higher magnification it is obvious that CRP immunoreactivity was located in the cytoplasm and not in the nucleus. Scale bar 100 µm, 50 µm and...
To be effective, drugs must cross the blood-brain-barrier, specifically target tumour cells and be devoid of too severe off-targets effects. However, if we carefully look to the in vitro test used to predict the ability of the drugs to hamper glioma invasion, we can observe that most of ...
Intracellular events leading to cell death is illustrated below the phospholipid membrane. Abbreviations: PE-L = Pseudomonas exotoxin A, fused to a cancer-specific ligand; Ab = antibody; EF2 = eukaryotic elongation factor-2 on ribosomes; Mcl1 = gene encoding anti-apoptotic protein; BAK = Bak ...