We argue that crucial to this task is an approach to ontology that treats it not as a question of first principles, but as a matter of the consequences of the images of nature that contemporary biomedical research practices espouse when they make claims to evidence, as well as the possible ...
For instance, there is an ongoing clinical trial in Atlanta Georgia at Emory University Medical Center using MSCs derived from bone marrow aspirate of “blood stem cell patients” (after having received a “stem cell transplant” for a blood cancer condition). These patients are on high dose pr...
Interleukin-1 (IL-1) is an inflammatory cytokine that promotes bone resorption and up-regulates RANK and RANKL [40]. Interleukin-7 (IL-7) and TNF-α can only up-regulate the expression of RANKL, so they are considered as osteoclast factors, while interleukin-4 (IL-4), Interleukin-13 (...
One example of an interventional study is a randomized control trial (RCT). During a randomized control trial, human subjects are chosen at random to receive an intervention. Generally, participants are arbitrarily placed into one of two groups: the experimental group receiving the intervention that ...
Nevertheless, there remains a clear need for high quality RCTs with enough patients below the age of 40 actively trying to conceive to confirm these outcomes. UAE and adenomyosis Adenomyosis is often present concurrently with uterine fibroids. Given the efficacy of UAE in fibroid disease, it has...
RCT = Randomized clinical trial. From [4]. Levels of evidence is closely related to our current concepts on “Evidence Based Medicine (EBM)”. Sackett in 1997 wrote EMB “…whose philosophical origins extend back to mid-19th century Paris and earlier, is the conscientious, explicit and judicio...
However, there is diversity in methods and stated definitions, so that, as it stands now, stakeholders cannot necessarily know what to expect if they commission an evidence map or seek to identify existing maps.Abbreviations GEM: Global Evidence Mapping. MeSH: Medical Subject Headings PROSPERO: ...
K.M is an employee of Evidera, which was funded by Pfizer to undertake the expert survey reported in this article. B.H. and S.W. are employees of Pfizer. J.M.G.S is a board member at the International Association of Health Preference Research. M.B, N.L.C, J.M.G.S, C.G-O...
34 Publication bias frequently leads to an overestimate of benefit. The next major challenge is that, in the absence of a large RCT with narrow confidence intervals, any conclusion frequently requires the analytical handling of multiple studies, frequently with conflicting outcomes, using an evidence-...
This study was carried out at the Almazov National Medical Research Centre (ANMRC) as part of the ongoing RCT "Genetic and epigenetic mechanisms of developing gestational diabetes mellitus and its effects on the fetus" (GEM GDM) which started in July 2015. ...