stroke, also called a lacunar infarct, occurs when an artery that supplies blood to the deeper portions of the brain becomes blocked. Other types of strokes occur on the surface, or cortex, of the brain. Lacunar strokes represent anywhere from 15% to 25% of strokes. What Is a Lacunar Str...
Ischemic stroke lesion volume at follow-up is an important surrogate outcome for acute stroke trials. We aimed to assess which differences in 48-hour lesion volume translate into meaningful clinical differences. We used pooled data from 7 trials investigating the efficacy of endovascular treatment ...
What is a pragmatic trial; Difference between a pragmatic trial and a explanatory trial; Why bias is generally not seen in a pragmatic trial; Outcome measures differences between explanatory and pragmatic approaches.关键词: Selection Bias Clinical Trials as Topic ...
In the updated, reimagined understanding of type 2 diabetes described herein—and based on state-of-the-art science—hyperglycemia is not a single entity, as it is usually regarded. Rather, it exists as an aggregate of drivers that contribute to the ensuing hyperglycemia. This is not a novel ...
Bivalirudin is an alternative to heparin in patients undergoing percutaneous coronary intervention (PCI). We aimed to define the effects of a bivalirudin-b... MA Cavender,MS Sabatine - 《Lancet》 被引量: 200发表: 2014年 Meta-Analysis Comparing Bivalirudin Versus Heparin Monotherapy on Ischemic and...
The planning of a clinical trial depends on the question that the investigator is addressing. The general objective is usually obvious, but the specific question to be answered by the trial is often not stated well. Stating the question clearly and in ad
In the updated, reimagined understanding of type 2 diabetes described herein—and based on state-of-the-art science—hyperglycemia is not a single entity, as it is usually regarded. Rather, it exists as an aggregate of drivers that contribute to the ensuing hyperglycemia. This is not a novel...
The risk of a recurrent stroke after transient ischemic attack (TIA) or minor stroke is high. Clinical trials are needed to assess acute treatment options in these patients. We sought to evaluate the type of recurrent events and to identify which subsets of patients are at risk for recurrent ...
Cardiac regeneration may have a role to play in these patients with a huge unmet need for these therapies in patients with chronic ischemic heart disease, post-infarct heart failure, dilated cardiomyopathy, and heart failure with preserved ejection fraction. Recent Findings In this review, we focus...
Regenerating the failing heart by promoting CM cell-cycle re-entry is an ambitious solution, currently vigorously pursued. Some genes have been proven to promote endogenous CM proliferation, believed to be preceded by CM dedifferentiation, wherein terminally differentiated CMs are initially reversed back...