There is an on-going debate about pharmacokinetic and pharmacodynamic (PK/PD) optimization. On the one hand, the critically ill patient has a higher than normal volume of distribution, impaired renal and hepatic clearance, altered plasma protein content and they also tend to be elderly with signi...
Although the new analogues of existing classes, and novel combinations, have been designed to address specific resistance problems, it is by no means certain than they will not be affected by the general mechanisms of resistance, particularly decreased net flux across the Gram-negative outer ...
There is an expression I like that goes like this: “Life is not measured by the number of breaths we take but by the number of moments that take our breath away.” Last Wednesday night was one of those moments. Let’s do it again, Ken, and soon!
First, the MVO during clockwise recoil is caused by the wrap—initiating when LV negative dP/pt starts, rather than when a LV pressure falls below left atrial pressure. Second, the entire ventricle does not relax—ongoing strain measurements and sonomicrometer crystal recordings confirm outer ...
¿Qué datos confidenciales existen en el sistema de la base de datos? ¿Cuántos? ¿Dónde residen? Loscontroles descriptivossupervisan el acceso de los usuarios y las aplicaciones a los datos, identifican comportamientos anómalos, detectan y bloquean amenazas y auditan la actividad de la...
Los externos incluyen a cualquier persona, desde hackers que actúan en solitario hasta ciberdelincuentes que tratan de interrumpir las operaciones de negocio u obtener un beneficio económico, u organizaciones criminales y patrocinadas por estados nación que buscan cometer fraudes para crear ...