which play an important role in maintaining self-tolerance and regulating the overall immune response to infection or tumor cells. In patients with MM, there are abnormalities in the number, function and distribution of Tregs, and these abnormalities may be related...
As this type of model is a whole living organism, it is expected that they intrinsically “capture the intricacies of the tumor immune response and microenvironment” [40]. This on its own is one the most important advantages of model organisms, which do not need the design of an ...
This opened up the possibility of “targeted therapy” in which the drug would only modulate the pathway for which it was intended. One aspect of this scenario is called “synthetic lethality”, where perturbing two or more cellular targets concurrently would be expected to result in loss of ...