COVID-19 is an emergent disease with many unknown aspects of its pathogenesis, and the main therapeutic approaches [8], consist of immunotherapies and antivi- ral drugs. Notwithstanding, the absence of a single spe- cific antiviral therapy for CoV resides in its novelty since COVID-19 was ...
1A). Restricted to primates, alternative splicing of the H2AFV gene produces an isoform called H2A.Z.2.2, which has a shortened and unique C terminus. This alteration leads to destabilization of the nucleosome structure when H2A.Z.2.2 is incorporated into chromatin (15, 16). Download: ...
A clear diagnosis and explanation of motor and/or sensory functional neurological disorder is validating and an important first step in recovery. People with motor and/or sensory functional neurological disorder experience significant disability, stigma, self-blame and functional impairment. Multidisciplinary...
Idle time has been defined as “involuntary downtime during which in-role tasks cannot be done” (Brodsky & Amabile,2018, p. 3). A key aspect of this definition is that idle time has to be involuntary, in that it occurs due to external factors, while employees are generally capable and...
First, we will show that while yes/no declaratives (YNDs) do indeed request confirmation, they can also create an environment in which the interlocutor can provide additional talk, and in fact when that talk is not provided, it can be pursued. Second, we will argue that YNDs that ...
The 401K contribution limit is the maximum amount an individual can contribute to their 401K account in a given year. For 2021, the limit stands at $19,500 for individuals under the age of 50. If you’re 50 years or older, you may be eligible to make additional “catch-up” contributio...
1 Sudden cardiac arrest (SCA) is a condition where a person’s heart stops beating without warning due to an electrical failure in the heart.2 Time-to-treatment plays a pivotal role in survival from cardiac arrest which occurs outside the hospital; every minute of delay results in a 10% ...
In this Forum, a group of experts on the cellular mechanisms of memory were invited to present their views on “what is memory”, including where and how memory engrams are stored, consolidated, and retrieved. Drawing on an elegant set of studies, Michele Pignatelli, Tomás Ryan, and Susumu...
protein-coding gene. This is interpreted as purifying selection if less than 1; positive selection if greater than 1; and neutral evolution if effectively 1. The numbers of substitutions are estimated by counting the observed differences in orthologous genes identified in at least two different ...
themselves can have an immune-modulatory effect(s) activating or inhibiting CDs such as PLGA. Second, NP-based nose-to-brain smart delivery of the formulated and characterized intranasal NPs carrying immuno-modulatory drugs could be used, which is an approach that our group is working on ...