Antibiotic selection of ESBL-producing Gram-negative pathogens is not just related to the total use of antimicrobial agents in hospitals, but also to the particular use of the fluoroquinolones and second- and third-generation cephalosporins [16]. P. aeruginosa has an extensive capability to become ...
Molecular identification of extended spectrum β-lactamases (ESBLs)-producing strains in clinical specimens from Tiruchirappalli, India Worldwide, the phenomenal antimicrobial resistance with its consequences of fatal diseases has been alerted; it is because the morbidity and mortality at a shocking rate....
Although similar to any other organism, prokaryotes can transfer genes vertically from mother cell to daughter cell, they can also exchange certain genes horizontally. Genes can move within and between genomes at fast rates because of mobile genetic elements (MGEs). Although mobile elements are fund...
Although similar to any other organism, prokaryotes can transfer genes vertically from mother cell to daughter cell, they can also exchange certain genes horizontally. Genes can move within and between genomes at fast rates because of mobile genetic elem
In this case, geneticists frequently call an organism resistant after the mutant strain exhibits an MIC for the selecting antibiotic that is consistently higher than the MIC for this agent when tested against the wild type parent. When this occurs in a clinical isolate, should an organism be ...
In addition, there is considerable activity around the discovery of novel classes of β-lactamase inhibitors with 10 combinations representing 4 inhibitor classes, at different stages of development. The combination of such inhibitors, which have broad activity against serine β-lactamases and may even...