Investigate key stages of a reaction or process, such as reaction start, induction period, accumulation, conversion and endpoint. Detect reaction stalling or upsets. Rapidly determine the effect of variables on reactions. Enhance understanding of solution crystallization processes with ReactRaman for monit...
2022). Prasinezumab (PRX002), a C-terminal antibody, missed its primary endpoint in the phase 2 trial (change of MDS-UPDRS I-III after 52 weeks; NCT03100149), yet showed a trend to slow decline in motor function (MDS-UPDRS part III). Therefore, efficacy of prasinezumab is currently...
Lifestyle interventions (including diet, exercise and behavioural changes) are the cornerstone of obesity management with diverse benefits, but even the most intensive lifestyle interventions result in up to 10% mean weight loss (WL) and weight maintenance remains a challenge, as 80% of WL is ex...
Indoleamine 2,3-dioxygenase 1 (IDO1), a monomeric heme-containing enzyme, catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan metabolism, which plays an important role in immunity and neuronal function. Its implication in d
Why does the titration endpoint color fade after 30-60 seconds? In an experiment with a titration of Vitamin C with Iodine, why must the iodine dropper be standardized? Explain the advantages of a potentiometric titration over titration...
Real-time PCR records the amount of fluorescence emitted during the reaction where all PCR components are abundant. In this way, Cqvalues are usually consistent across replicates in real-time PCR. By the time the PCR reaction endpoint is reached, accumulated inhibitors, inactivated polymerases, and...
Strictly speaking, you cannot take the log of an amount with dimensions. pH is also unusual in that the log value is in itself an endpoint. VOTE Damien LeimbachFollow Firstly, just because it can be measured does not mean it "MUST have a unit", SI or otherwise. It is a derived measur...
The first endpoint was to determine a statistically significant difference in terms of serum 25(OH)D3 levels among SARS-CoV-2 healed patients (Group 3; h-COVID-19), SARS-CoV-2 infected patients (Group 1; COVID-19) and patients never infected by SARS-CoV-2 (Group 2; no-COVID-19)....
It targets hepatic ANGPTL3mRNA interacting with the asialoglycoprotein receptor and can develop favorable cardiometabolic effects in patients with atherosclerosis [95]. Although the product met the primary endpoint of the Phase IIb TRANSLATE-TIMI 70 clinical trial (that included statin-treated subjects ...
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