IL-10 is an activated macrophage and dendritic cell inhibitor, and acts as an effective inflammatory response regulator. Following a bacterial endotoxin or intact bacteria challenge, mice that are deficient in IL-10 display hyper-inflammation. Supplementation with exogenous IL-10 increases the anti-...
Biofilms are unique, multicellular life forms that challenge our understanding of the microbial functioning. The last decades of research on biofilms have allowed us to better understand their importance in the context of both health and various pathologies in the human body, although many knowledge ...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook AcronymDefinition IPAAInstrument for Pre-Accession Assistance(EU) IPAAIndependent Petroleum Association of America IPAAInstitute of Public Administration Australia ...
Diabetic macular edema (DME) is an ocular complication of diabetes that develops over a period of time.
@NathanG - I’ve heard of that too. The only challenge that I see for using nanoparticulates as drug carries is that the technology is still new, and nanoparticles operate at the quantum level. What this basically means is that they operate at a level where quantum mechanics takes over, ...
There are patients who experience major bleeds and some who have frequent minor bleeds, and our challenge is to address the different needs of the bleeders. In the following sections, we describe several potential approaches that could change the current paradigm of how VWD is treated or can ...
Under an Elsevier user license open archiveThe glomerular filtration barrier (GFB) is characterized by a very high hydraulic permeability, combined with a marked permselectivity that excludes macromolecules such as albumin. Thus, the GFB retains most of the plasma proteins, with only 0.06% of albumin...
Management of NP is a challenge. Control of NCP usu- ally requires higher doses of opioids then what is tolerable, thus the need for adjuvant analgesics or coanalgesics. The coanalgesic drug group include gabapentinoids (gabapentin, pregabalin), antidepressants (TCAs, du...
The latest advance in the development of targeted mABs is the bsABs, which can target two different antigens. Targeting two different tumor-associated antigens can help overcome the challenge of clinical resistance seen with cancer treatments [47]. A subcategory of bsABs, the bispecific T-cell...
In the illustration here, we have BPA (bisphenol A, which is found in many plastic products) binding to human tissue. For instance, BPA has been shown to have an affinity for binding to human albumin. Once it is bound to the tissue, that tissue now appears as a foreign antigen to the...