Alpha galactosidase is an enzyme used in digesting sugars in vegetables and grains. If a person's body doesn't produce alpha...
Beano (alpha-galactosidase) is a supplement consisting of natural enzymes which assist in both preventing flatulence, abdominal bloating, stomach pain, and a distended stomach. The primary ingredient in Beano is the natural enzyme alpha-galactosidase. What kind of enzyme is alpha-galactosidase? Alpha-...
The mutations, however, result in an alpha-galactosidase A deficiency that causes Gb3 to toxically accumulate in the lysosome. The condition is thus a lysosomal storage disorder, referring to a group of diseases where defects in one or more enzymes in the lysosomes cause substances to accumulate...
Objective: Fabry disease is a rare hereditary lysosomal storage disease caused by the deficiency of alpha-galactosidase A (伪-GLA). Although sensorineural hearing loss is common in Fabry disease, there are no studies in the literature that have screened a population with sen...
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[53] Alcalay RN, Wolf P, Levy OA, Kang UJ, Waters C, Fahn S, Ford B, Kuo SH, Vanegas N, Shah H, Liong C, Narayan S, Pauciulo MW, Nichols WC, Gan-Or Z, Rouleau GA, Chung WK, Oliva P, Keutzer J, Marder K, Zhang XK (2018) Alpha galactosidase A...
Deficiency of Endothelial Cxcr4 Reduces Reendothelialization and Enhances Neointimal Hyperplasia After Vascular Injury in Atherosclerosis-Prone Mice This study aimed to investigate the role of endothelial Cxcr4 in neointima formation.尾-Galactosidase staining using bone marrow x kinase (Bmx)-CreER(T2)......
Fabry Disease (FD) is an X-linked lysosomal storage disorder, caused by mutations in the GLA gene, leading to a deficiency in α-galactosidase A enzyme activity. This deficiency causes an accumulation of glycosphingolipids, primarily globotriaosylceramide, in lysosomes across various cell types...
Anderson–Fabry disease (AFD) is an X-linked lysosomal storage disorder, caused by deficiency or absence of the alpha-galactosidase A activity, with a consequent glycosphingolipid accumulation. Biomarkers and imaging findings may be useful for diagnosis, identification of an organ involvement, therapy...
SASP factors such as TNFalpha, IL-1alpha, IL-1beta, IL-6, IL-8, matrix metalloproteinases (MMPs), and loss of nuclear localization of HMGB1 are also commonly used senescence markers. Additional markers include senescence-associated beta-galactosidase activity due to increased lysosomal content and...