Cuthbertson DJ, Steele T, Wilding JP, Halford JC, Harrold JA, Hamer M, Karpe F: What have human experimental overfeeding studies taught us about adipose tissue expansion and susceptibility to obesity and metabolic complications? Int J Obes 2017;41:853-865....
As you yourself said, this is in its infancy. Paul Reply Nick Fedan June 30, 2019 at 11:46 pm Admin: Would not allogeneic bone marrow MSCs be more than “minimally manipulated” by culture expansion? And when injected in the knee,or shoulder, or as an IV, would not that be non...
The Beta-Cell–Centric Model: The Egregious Eleven. Dysfunction of the beta cells is the final common denominator in DM. Eleven currently known mediating pathways of hyperglycemia are shown. Many of these contribute to beta cell dysfunction (liver, muscle, adipose tissue [shown in maroon to depic...
In the process of diet-induced obesity, adipocytes undergo major structural and functional changes, including hypertrophy, which leads to adipose tissue expansion, resulting in inefficient blood flow to the tissue3. This may then create tissue hypoxia, in which the affected cells in adipose tissues,...
Adipose Tissue Expansion in Obesity: Go Big versus Go Forth and Multiply! One of the unique attributes of adipose tissue is its incredible capacity to change its dimensions; no other nonneoplastic tissue shares this feature to the same degree. In principle, this can be accomplished by increasing...
Energy intake is associated with endotoxemia in apparently healthy men. Am. J. Clin. Nutr. 87, 1219–1223 (2008). Article CAS PubMed Google Scholar Saberi, M. et al. Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in ...
MSCs are adult stem cells that have self-renewal, immunomodulatory, anti-inflammatory, signaling, cell division, and differentiation properties.MSCs self-renewal capacity is characterized by their ability to divide and develop into multiple specialized cell types in a specific tissue or organ. ...
It has been shown in experimental models that CKD is associated with significant reduction in mRNA expression and protein abundance of GPIHBP1 in skeletal muscle, myocardium and adipose tissue (43). In addition, in subjects with CKD, increased levels of parathyroid hormone and insulin resistance ...
An organ is a structure in the body that has, at minimum, two different kinds of tissues that function together for the same purpose. The kidneys, the heart and even skin are all organs. A human actually has two circulatory systems: a short loop running
By contrast, brown adipose tissue (BAT), which is located mainly in the interscapular region in humans and mice, is composed of a type of adipocyte that contains numerous mitochondria and multilocular lipid droplets. The major function of brown adipocytes has been described as burning substrates...