Genome editingis a type of geneticengineering where a DNA is inserted, deleted or replaced in the genome of aliving organism. The application of this technology has revolutionized variousresearch areas ranging from biomedicine to biotechnology or synthetic biology.A key point to initiate the editing ...
Fatty liver or hepatic steatosis is increasingly diagnosed worldwide. In addition to histology, noninvasive techniques, such as ultrasound, computerized tomography magnetic resonance imaging and proton magnetic resonance spectroscopy, can be used to detect this disease [1]. A Japanese study showed that ...
2020). The loss of two disulfide bonds in the eight-cysteine motif (8-CM) that is conserved among the nsLTPs causes growth inhibition in Ptd1 mutants, and Ptd1 may be important for pathways required for cell division and elongation. However, how Psd1 exerts a dominant effect for growth ...
Like the other nuclear receptors, the DNA-binding domain of the androgen and glucocorticoid receptors consist of two zinc finger modules. The first recognizes a response element characterized by a hexameric motif, while the second is involved in receptor dimerization. While their sequence specificity ...
Zinc Zinc range hoodcovers are notable for their eye-catching, bluish-white shine and corrosion resistance. They have a distinctly industrial look, similar to that of old stovepipes.This unique custom hood material is highly long-lasting and can withstand high temperatures, making them ideal for ...
(PRC) 2 to stably silence the stem cell regulators [99]. TheAS2gene encodes an AS2/LOB domain-containing protein comprising a cysteine repeat motif and a leucine-zipper-like sequence in its amino-terminal half [100]. Hence, the multiple levels of regulation may explain the crucial role that...
The retina is also more accessible than other areas of the central ner- vous system, thus making it a simpler model to work with and study. By utilizing the retinal model, we can greatly increase our knowl- edge of the cell death processes initiated by ischemia which lead to degeneration ...
Moreover, a highly conserved arginine residue in motif VI, termed “arginine finger”, specifically interacts with the γ-phosphate of the incoming NTP. Relative to motifs I, II, and Q this residue is located on the opposite side of the NTP-binding cleft formed by domains 1A and 2A (Fig...
On the other hand, we identified a C[X.sub.4]C[X.sub.22]HXH zinc finger motif in subgroup In and IIx genes, a C[X.sub.4]C[X.sub.23]HXH motif in subgroup Ic and IIe genes, and a C[X.sub.5]C[X.sub.23] HXH motif in subgroup IIa, IIc, IId, and IIe genes (Figure ...
What makes HDAC6 unique among all HDAC enzymes is the presence of the C-terminal zinc finger domain able to recognize unanchored C-terminal diglycine motif of ubiquitin characterizing aggresomes [29, 33]. This domain, recently solved by X-ray, alone and in complex with ubiquitin, is formed...