Genome editingis a type of geneticengineering where a DNA is inserted, deleted or replaced in the genome of aliving organism. The application of this technology has revolutionized variousresearch areas ranging from biomedicine to biotechnology or synthetic biology.A key point to initiate the editing ...
from a small bulge on the SAM, into a fully developed lateral outgrowth with diverse shapes. Although poorly understood, herbivory is another factor contributing to leaf shape variation [6]. Due to continued interest in this area of research...
The latter include the three common eukaryotic DNA-binding motifs, namely the helix-turn-helix motif, the zinc finger motif and the basic helix-loop-helix protein containing a leucine zipper motif. Such chimeric nucleases have been shown to make specific cuts in vitro very close to the expected...
2020). The loss of two disulfide bonds in the eight-cysteine motif (8-CM) that is conserved among the nsLTPs causes growth inhibition in Ptd1 mutants, and Ptd1 may be important for pathways required for cell division and elongation. However, how Psd1 exerts a dominant effect for growth ...
Definition, origin, and evolution of a leaf From a layman’s perspective, ‘leaf’ is a flattened, green-colored structure laterally attached to the stem. This perception may be too simple considering the remarkable diversity that leaves exhibit. As a prerequisite to their review on angiosperm le...
This review provides a detailed overview (Han and Kim 2019). What makes CRISPR-Cas the most powerful gene-editing technology? CRISPR-Cas technology, unlike zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), is an RNA-based gene modification system (Jinek et...
What makes HDAC6 unique among all HDAC enzymes is the presence of the C-terminal zinc finger domain able to recognize unanchored C-terminal diglycine motif of ubiquitin characterizing aggresomes [29, 33]. This domain, recently solved by X-ray, alone and in complex with ubiquitin, is formed...
The retina is also more accessible than other areas of the central ner- vous system, thus making it a simpler model to work with and study. By utilizing the retinal model, we can greatly increase our knowl- edge of the cell death processes initiated by ischemia which lead to degeneration ...
NEXT is composed of three subunits: MTR4 helicase, zinc finger protein ZCCHC8, and RNA-binding protein RBM7 (Lubas et al., 2011). Both studies illuminate that NEXT forms a dimer and adopts a flexible two-lobe architecture, with each protomer consisting of MTR4-ZCCHC8-RBM7 and target RNA...
Like the other nuclear receptors, the DNA-binding domain of the androgen and glucocorticoid receptors consist of two zinc finger modules. The first recognizes a response element characterized by a hexameric motif, while the second is involved in receptor dimerization. While their sequence specificity ...