therapeutic equivalenceThe problem of generic drugs use in clinical practice and confirmation of their therapeutic equivalence is discussed. The significance of studies on generic drugs bioequivalence, as well as details of international practice and regulations in this area is explained....
capsule is a type of capsule used primarily for the treatment of mild to moderate primary hypertension. This medication is a prescription drug and should be taken under the guidance of a doctor. It is important to follow the prescribed dosage and usage instructions strictly. So, what is the ...
It is used to extend the effective patent life of a drug. Methods Search strategy The search strategy for the review was developed with guidance from a librarian who is an expert on systematic reviews. A scoping exercise was first undertaken to develop and revise the search terms. The review...
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder that is characterized by abdominal pain and an altered defecation pattern. It affects between 5 and 20% of the general population and can seriously impact quality of life. T
What is a nocebo effect?A nocebo effect is the opposite of the placebo effect -- a negative psychological effect of a treatment with "no" therapeutic activity. This can occur when the placebo is administered and accompanied by the suggestion that the patients ailment will get worse. High ...
This work devises a model to assess the ‘relative microbiota maturity index’ as a marker for malnutrition and the efficacy of therapeutic intervention. Article CAS PubMed PubMed Central Google Scholar Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L. & Gordon, J. I. ...
We need better compounds going into clinical trials, including the right dosing/PK for achieving a safe therapeutic index, which involves selection via efficacy and safety-relevant end points (not just by using proxy measures that are easy to generate but not informative about these aspects). In...
Contrary to popular thought, people don’t choose to develop obesity; most people don’t wake up one morning and think, “Hey, today is a good day to become overweight to the point where it might damage my health and well-being.” Obesity is a result of a complex back-and-forth inter...
name medications. Of greatest importance is the fact that generic medications have the same active pharmaceutical ingredient (API) as their brand name counterparts. The API is the main ingredient in a drug that impacts the body to treat a medical condition or prevents a patient from getting...
T-cell-targeted therapy is also showing early results. The antagonist abatacept, which targets cytotoxic T-cell-associated protein 4 (CTLA-4), has shown therapeutic effects in SLE in preclinical animal studies or clinical applications, although its efficacy was not confirmed in phase II and phase...