In healthy cells, DUX4 can produce a short mRNA isoform that is translated into a nontoxic protein. In FSHD myocytes, there is a shift in mRNA splicing to generate the full-length, pathogenic DUX4 isoform (DUX4-fl). Initial studies geared toward therapy showed that siRNAs and antisense ...
For example, if your theriotype is a parrot, during your shift, you might lose your independent thought and start repeating other people, feel like you have feathers instead of skin, or randomly start visualizing yourself on a subtropical island. Some therians also experience dream shifts, wher...