Lymphatic clearance is dependent on activity of lymphatic smooth muscle cell pumping and functional uni-directional valves. During Inflammation, cytokines induce fibroblast-dependent relaxation and disassembly of the integrin-collagen complex, that promotes Interstitial Expansion and a more negative pressure (...
In mice, RV infection resulted in goblet cell metaplasia, poor interferon β production, and attenuated viral clearance that was absent in FOXA3−/− animals [96]. Goblet cell hyperplasia is a hallmark of Th2 inflammation that is largely driven by IL-13 [97,98,99]. The shift toward ...
Therefore, autophagy is a fine-tuning molecular mechanism that is directly related to the inflammatory response/inflammasome. Autophagy inhibition is required to avoid COVID-19 inflammatory response [63]. ATG5 or ATG7 controls autophagosome formation and is not necessary for viral replication in SARS-C...
“first-hit”, linked to obesity, insulin resistance and metabolic syndrome, while the “second-hit” is activated by hepatic inflammation, together with oxidative stress and endotoxemia, which have a key role in the progression to non-alcoholic steatohepatitis (NASH) and, over time, to fibrosis...
The retina is also more accessible than other areas of the central ner- vous system, thus making it a simpler model to work with and study. By utilizing the retinal model, we can greatly increase our knowl- edge of the cell death processes initiated by ischemia which lead to degeneration ...
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mimicry has been used to show that SGLT-2 inhibitor modulation of mitochondrial function and viability involves processes of autophagy, the clearing of reactive oxygen species, and the reduction of inflammation and fibrosis, each of which is a pathway distinct from the renal clearance of glucose [...
The precise cellular function of CLN3 is not completely known. CLN3 has been primarily found in endosomes and lysosomes with a suggested involvement in endocytosis and endocytic trafficking [50], [70], [71], [72], [73], [74]. The yeast ortholog of CLN3, Btn1p, has been shown to ...
It is nowadays a common practice to “work without sleep and catch up later.” It is not a good idea to keep up with sleep deficit. In recent years, several reports have shown that the consequences of chronic sleep loss are not reversible. It may...
Abstract As the HIV population continues to live longer as a result of antiretroviral therapy, liver-related mortality has become one of the leading causes of non-AIDS related death in this patient population. The liver possesses a remarkable regenerative capacity but undergoes complex biological chang...