Prior to AFDB, teams of scientists would spend months, even years, solving a structure of a single protein, whereas nowadays, thanks to AFDB, protein structure is often taken as a given. However, we and others [Citation26] advise caution given that, although informative, all structural models...
Autoantibodies and lupus-like syndromes can develop following the use of certain medications; however, although many patients develop autoantibodies, only a minority develop clinical features. Although these autoantibodies primarily consist of antinuclear and antihistone antibodies, additional types of antibody...
What is \textbf{Histone}? What is the retina and where is it located? Where is the best place on Earth to run a marathon? Explain why in detail. What is a subtropical high? a. What does the control center do? b. What can it not do? What is a lipoprotein profile? What are Hassa...
This adds a large (76 amino acid) molecule to the DNA–histone interface. FLP recombinase A site-specific recombinase that is used to engineer specific DNA rearrangements in living organisms. Chromatin immunoprecipitation (ChIP). Method for detecting sites of chromatin binding. Cells or tissues are...
When we looked into the top 100 products by antibody type, we noticed some trends. Thenumber of recombinant antibodies in the data has increasedfrom last year, with this antibody type now making up a quarter of the list. This is to be expected, mirroring the trend of more recombinants bei...
Background [1-3] MG-132 subunit PI31 antibody is a type of polyclonal antibody that can specifically bind to MG-132 subunit PI31. It is mainly used i..
In a first scenario, where no mRNA is detected but protein expression is high, the discordance could be due to non-specific staining brought about by a promiscuous polyclonal antibody or IHC protocol failure, especially in the blocking step. The antibody could have low binding affinities leading ...
We included the histone H3 antibody as a nonspecific antibody to either ACTH receptor orGHRHR, which served as a negative control [see Supplemental Material, Figure 4 (doi:10.1289/ehp.0900738)]. Atrazine binds to the growth hormone-releasing hormone receptor and affects growth hormone gene expressi...
In early 1996, I found a short cDNA sequence in the EST database that looked similar to the Myb domain of TRF1. Could there be a second TRF? I considered this unlikely because I had done super-shift experiments with a TRF1 antibody; all the detectable HeLa dsTTAGGG-binding activity was...
Small-cell lung cancer (SCLC) is a deadly cancer associated with smoke exposure that has neuroendocrine (NE) cell properties and is pathologically, molecularly, biologically and clinically very different from other lung cancers. While most patients with SCLC respond initially to cytotoxic therapy, almo...