Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α1A subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α1A subtype accounts for approximately 75% of α1-...
QTc is equal to QT interval in seconds divided by the square root of the preceding RR interval in seconds. When heart rate is par- ticularly fast or slow, the Bazett’s formula may overcorrect or undercorrect, respectively, but it remains the standard for clinical use. The cube root ...
Douglas Thomson, trademark attorney at Marks & Clerk, added: “Cybersquatting – whereby opportunists buy up branded domain names in the hope of re-selling them – is a problem across the net, but has the potential for uniquely embarrassing and damaging consequences in this case. “The only ...
In pharmacology, the ceiling effect for a drug is reached when further increments of the drug has diminishing desired effects and may start to have unwanted side effects. Opioids are begun at starting doses, and increased to reach the effective dose. Pure agonists have a wide therapeutic dosing...
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Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α1A subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α1A subtype accounts for approximately 75% of α1-...