is expressed about equally in both healthy and diseased tissue. Researchers can use this information to determine which genes are more active in a diseased cell and how such changes affect other genes in the cell. Genome microarrays can be used not only to research and diagnose diseases such ...
Genome sequences and evolutionary biology, a two-way interaction, by Deborah Charlesworth, Brian Charlesworth and Gilean A.T. McVean (Trends Ecol. Evol.)The grand design, by Zoltan Szallasi (Trends Pharm. Sci.)The human medicine project has started: place your bets now, by Allen D. Roses...
While sequencing of the human genome surprised us with how many protein-coding genes there are, it did not fundamentally change our perspective on what a gene is. In contrast, the complex patterns of dispersed regulation and pervasive transcription uncovered by the ENCODE project, together with non...
Today, scientists no longer speak of the sequence hypothesis. Instead, the notion thatnucleotidesequences (genes) directly dictate amino acid sequences is known ascolinearity(Figure 1). Scientists have confirmed that colinearity is a regular occurrence among many viruses, like the ones Benzer studied...
A genome is an organism’s full set of DNA, comprising all of its genes as well as its hierarchical, three-dimensional structure. Genomics is an interdisciplinary field of biology that focuses on the structure, function, evolution, mapping, and editing of genomes. ...
Data considerations for Human Genome Sequencing Introduction to NGS methods and techniques Next-generation sequencing (NGS) is a technology for determining the sequence of DNA or RNA to study genetic variation associ...
This section provides a quick introduction of gene, which is a section of a double helix DNA structure that contains a specific sequence of base pairs representing a specific coded instruction to construct building blocks for living organisms.©...
Missense mutations are genetic mutations in which a single base is replaced with another one, which typically causes...
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The Human Genome Project In the field of biology, the term “sequencing” refers to the determination of the sequence of units of a linear polymer. DNA sequencing, therefore, is the use of methods and technologies to determine the identity and order of the four nucleotide...