authoritative location to a decentralized system in which all relevant entities can view and modify the ledger. As a result, all other entities can see who is using and modifying the ledger. Thistransparencyof DLT provides a high level of trust among...
Development of blockchain and DLT may add decentralized mechanisms for identifier and data sharing. More ambient intelligence will evolve decision making towards autonomy. Growth ofaugmented realityand brain-computer interfaces will drive immersive control. ...
Historically, an MTD is identified in the first-in-patient study via a dose escalation design where cohorts of 3 patients are given increasing drug doses until 2 of the 3 patients experience a dose-limiting toxicity (DLT), which is usually defined as a severe...
Worldwide, further scrutiny of the economic impact of DLT for BCRL in clinical settings is needed.Clinical trial registration numberThe review makes part of a double-blind, multi-center, randomized controlled trial (EFforT-BCRL trial), which is registered in clinicaltrials.gov (NCT02609724). ...
2017年ASCO 报道了第一项First in human 剂量爬坡试验 DLT评估期间仅有一例患者出现剂量限制性毒性,该患者为宫颈癌,既往有放疗史和结直肠炎,并发了贫血和直肠出血。 MTD在3-20mg/Kg剂量范围内探索时并未达到 在3-20mg/kg 剂量范围内,对PD-L1具有高度亲和力 ...
Nevertheless, most patients show primary or acquired resistance to anti-PD-L1 therefore new promising therapeutic immune-targets are under clinical investigation in several solid tumors. Among these, B7-H3, also known as CD276, is a member of the B7 family overexpressed in tumor tissues, including...
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IPDlT IPDM IPDMA IPDMC iPDmi IPDMT IPDMUG IPDN IPDO IPDP IPDPF IPDPL IPDPS IPDR IPDRA IPDRC IPDS IPDSC IPDSI IPDSLAM IPDSMS IPDT IPDTA IPDTC IPDTI IPDU IPDV IPDVB IPDVMRP IPDWG IPDWR IPDY IPE IPE&TD IPE/SPE IPEA IPEAK ...
2017年ASCO 报道了第一项First in human 剂量爬坡试验 DLT评估期间仅有一例患者出现剂量限制性毒性,该患者为宫颈癌,既往有放疗史和结直肠炎,并发了贫血和直肠出血。 MTD在3-20mg/Kg剂量范围内探索时并未达到 在3-20mg/kg 剂量范围内,对PD-L1具有高度亲和力 ...