A protein chaperone, also known as a pharmacophore, is a pharmacological chaperone. A chaperone has a similar function in pharmacology... Learn more about this topic: Pharmacology | Definition, Branches & Importance from Chapter 1/ Lesson 32 128K...
The conformational state of a protein can be diagnosed from which type of protein? How is E2F protein regulated by cyclins and Rb protein? UV absorption is commonly used to detect proteins. Which amino acids listed below absorbs UV radiation the greatest? A) isoleuc...
Prion proteinligandscoppertransmissible spongiform encephalopathyprion functionPrion protein, a misfolded isoform of which is the essential component of the agent of prion diseases, still remains an enigmatic protein whose physiological functions are at best hypothetical. To gain a better insight into its ...
What is an aromatase inhibitor and how is it used? What are the goals of antiarrhythmic drug therapy? How does cross-reactivity affect drug test results? What is a chaperone in the context of pharmacology? Why does high salt concentration precipitate proteins?
Wntless, a chaperone protein required for clearance of Wnt protein secretion in the osteogenic stage, can lead to severe osteoporosis caused by the impaired bone formation and increased bone resorption [29]. β-Catenin is a crucial link in the Wnt/β-catenin signaling cascade. High levels of ...
Type III protein secretion in plant pathogenic bacteria. Plant Physiol. 150, 1656–1664 (2009). PubMed PubMed Central Google Scholar Glickmann, E. et al. Auxin production is a common feature of most pathovars of Pseudomonas syringae. Mol. Plant Microbe Interact. 11, 156–162 (1998). ...
Type III protein secretion in plant pathogenic bacteria. Plant Physiol. 150, 1656–1664 (2009). PubMed PubMed Central Google Scholar Glickmann, E. et al. Auxin production is a common feature of most pathovars of Pseudomonas syringae. Mol. Plant Microbe Interact. 11, 156–162 (1998). ...
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat. Genet. 36, 618–623 (2004). CAS PubMed Google Scholar Ye, J. Z. et al. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev. 18...
However, we learned that neither protein had anything to do with telomeres. Rif1 is a DNA damage–response factor as Josh showed (31), and Tel2 is a chaperone that regulates the stability of PI3K-related kinases as postdoctoral fellow Hiro Takai figured out later (32). Rich had given up...
The catalytic activity of the C subunit is decreased by a protein kinase inhibitor (PKI), which can also act as a chaperone and promote nuclear export of the C subunit, thereby decreasing the nuclear functions of PKA. PKA-anchoring proteins (AKAPs) provide specificity in cAMP signal ...