Wntless, a chaperone protein required for clearance of Wnt protein secretion in the osteogenic stage, can lead to severe osteoporosis caused by the impaired bone formation and increased bone resorption [29]. β-Catenin is a crucial link in the Wnt/β-catenin signaling cascade. High levels of ...
Today, PD is exclusively treated symptomatically, mainly by dopaminergic stimulation, while efforts to modify disease progression could not yet be translated to the clinics. New formulations of approved drugs and treatment options of motor fluctuations in advanced stages accompanied by telehealth ...
The same mRNA-protein abundance measure is observed for HSP90AA1 encoding for the molecular chaperone heat shock protein 90 alpha family class A member 1 (Fig. 2b) in the tubules (436.6 normalized transcripts-per-million in the Human Protein Atlas, 202 transcripts-per-million in Levin et al.)...