Background: Hashimoto's Thyroiditis a common disease that affects the thyroid gland. Recent studies on Hashimoto's Thyroiditis indicated the ability of miRNA to silence messenger RNA and regulate post-transcriptional processes. Objective: The aim of the current study was to...
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In this regard, miRNAs are considered as molecules that are important in all of the mentioned cases. miRNAs are small RNA molecules with 20 to 22 nucleotides. The gene encoding miRNAs is transcribed by RNA Pol II enzyme. The primary transcription of miRNAs (called Pri-miRNA) is converted to ...
miRNA expression with anti-inflammatory functions or inhibiting miRNA expression with pro-inflammatory functions. In this editorial, we present the main findings and future perspectives regarding miRNAs and their roles in IBD patients. Currently, there is no specific miRNA biomarker for IBD, nor is ...
Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods. Ulcerative colitis and Crohn’s disease are two major forms of the disease. IBD imposes a lot of sufferings on the patient and has many consequences; h
lncRNA = long noncoding RNA; MiRNA = microRNA; mRNA = messenger RNA. Table 1. Diverse Cardiovascular Sources of EVs: Bioactivity and Therapeutic Implications Cell Source of EVsBioactivity of EVsPotential Therapeutic IndicationsAuthor (Ref. #), Study Year Bone marrow dendritic cells Decreased T-...
The molecular characterization of poorly and anaplastic thyroid carcinomas has been greatly improved in the last years following the advent of high throughput technologies. However, with special reference to genomic data, the prevalence of reported alterations is partly affected by classification criteria....
The module that is negatively correlated with AD severity in the parahippocampal gyrus is enriched in cognitive impairment and pathology-related pathways. Liu et al. found that miR-574–5p in the peripheral blood of AD patients may be a potential miRNA target of circRNA hsa_circ_0003391, ...
Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Due to the shortage of effective biomarkers for predicting survival and diagnosing PC, the underlying mechanism is still intensively investigated but poorly understoo
Uveal melanoma (UM) is a rare ocular tumor. The loss of BRCA1-associated protein 1 (BAP1) and the aberrant activation of G protein subunit alpha q (GNAQ)/G protein subunit alpha 11 (GNA11) contribute to the frequent metastasis of UM. Thus far, limited mo