In the subgroup analysis by ethnicity for this locus, a highly significant risk was found in Asians and Latinos with the GG genotype, but not in Africans. Other studies also confirmed that MCP-1 −2518GG genotype associated with tuberculosis outcome and resistance [86], [91]. Nucleotide ...
The immunosuppressive function of Tregs depends on continuous expression of the transcription factor Foxp3, which is also a hallmark of the completion of Tregs differentiation [25]. Foxp3 controls the proliferation, inhibitory function and homeostasis of Treg cells by regulating oxidative phosphorylation ...
Ethnicity has been studied and European descent has been associated with a moderately increased risk of JIA; additionally, JIA subtypes differed significantly between ethnic groups [48]. There have been few developments in terms of environmental risk factors, although infection remains the most favoured...
Population health is also shaped by the demographic structure. Most of the demographic factors can be classified as downstream factors because they directly affect health (age, for example) and others may be socially constructed (ethnicity) and therefore share some characteristics of the upstream facto...
For older adults one of the primary concerns was expressed as a vulnerability relating to the possibility of being rejected by the children due to ethnicity or language difficulties. Some were concerned that the children may simply just not like them, or that all the children would all like ...
Ethnicity-related differences in tumor immunity: A new possible explanation for gastric cancer prognostic variability? Transl. Gastroenterol. Hepatol. 2016, 1, 11. [Google Scholar] [CrossRef] [PubMed] Janjigian, Y.Y.; Bendell, J.; Calvo, E.; Kim, J.W.; Ascierto, P.A.; Sharma, P.;...
Subjects with occasional or frequent consumption of curry performed better than those reporting rare consumption, and the effect was more pronounced in men and subjects with Indian ethnicity [123]. This appealing result was the basis for the first randomized double-blind, placebo-controlled trial on...
The US National Institutes of Health (NIH), since 1994, has required the inclusion of women and minority groups in all NIH-funded clinical trials, together with detailed incorporation of analysis stratified by sex, gender and ethnicity in research reporting [16]. The same has been advocated by...
However, the absolute measurement strategy outperformed the age-gender-ethnicity method, according to the MESA trial, even though both approaches produced effective risk categorization. In that study, even the lowest CAC (Agatston score of 1–10) was associated with a 3-fold increased risk of CAD...