Studieshave shown that CBD is metabolized by the CYP450 enzyme system, which includes CYP2C9, CYP2C19, CYP3A4, UGT1A9, UGT2B7, CYP2C8, CYP1A2, CYP2B6, CYP2D6, CYP2C8, CYP2E1, CYP3A, and CYP3A4 enzymes. Approximately 60% of prescription medications are also metabolized by these en...
Patients taking drugs with a narrow therapeutic index metabolized by CYP1A2 (e.g. theophylline and clozapine) should avoid taking them with E. purpurea. However, studies conclude that no clinically significant interactions were expected between E. purpurea and substrates of CYP2D6, CYP2C19 and CYP...
It may inhibit CYP2C9 and CYP2C19, which are involved in the metabolism of many nonsteroidal anti-inflammatory drugs (NSAIDs) which may include ibuprofen (Advil, Morin) and naproxen (Aleve), angiotensin receptor blockers (ARBs), glipizide (Glucotrol), glyburide (Glynase), rosiglitazone (Avan...
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CBD Can Affect How Certain Drugs Are Processed Studieshave shown that CBD is metabolized by the CYP450 enzyme system, which includes CYP2C9, CYP2C19, CYP3A4, UGT1A9, UGT2B7, CYP2C8, CYP1A2, CYP2B6, CYP2D6, CYP2C8, CYP2E1, CYP3A, and CYP3A4 enzymes. ...