This is due to the restricted ion gradient maintained across the neuronal membrane, as well as the efficient and effective removal of neurotransmitters from the synaptic clefts by glia. During reti- nal ischemia, however, the concentration of neurotransmitters, notably glutamine, in the extracellular ...
As the brain matures, one thing that happens is the pruning of the synapses. Synaptic pruning does not occur willy-nilly; it depends largely on how any one brain pathway is used. By cutting off unused pathways, the brain eventually settles into a structure that’s most efficient for the ow...
In adolescence, FC studies have also shown earlier maturation of cortical areas involved in motor control compared to areas involved in social and emotional functions (Kelly et al., 2009). Experience-dependent pruning of local circuitry (Huttenlocher, 1979) and myelination of long-range connections ...
loss of synaptic connections could contribute to a functional disconnection and loss of normal control of mood and emotion in depression (Fig. 1). In particular, the medial PFC exerts top down control over other brain
The answer to this question has to be a qualified yes. The nervous system is exceptionally complex and goes through a prolonged period of development characterised by cellular migration and differentiation, and synaptic pruning. The basic structures of the brain are formed in stages and the successf...
Brain development continues quite rapidly during childhood, and several important processes occur during this period, including synaptogenesis, synaptic pruning, dendritic arborization, and myelination (Huttenlocher 1990; Huttenlocher and de Courten 1987; White et al. 2010). Three large samples of twins...
It has been proposed that NAADP induces local EL Ca2+ release through TPC1-2 that is, in turn, amplified into a regenerative Ca2+ wave by the Ca2+-dependent recruitment of juxtaposed (<30 nm) InsP3R and RyR at quasi-synaptic ER-EL junctions [112,113]. The so-called "trigger ...