All in all, you did the work over the summer and you want to keep that wellness work and habit stacking going strong even as summer comes to a close. And you can.That may mean days where you have to make adjustments or days where you need a little push to keep yourself in check. ...
the brain remains maximally plastic and can develop in a variety of ways. But once those excess synapses are gone, the critical period is over, and it must make do with its existing circuitry; there is no trading up for a faster computer.整本书之后详细从以下几个方面讲了这个机制...
Dysregulation of synaptic pruning as a possible link between intestinal microbiota dysbiosis and neuropsychiatric disorders Journal of Neuroscience Research, John Wiley and Sons Inc (2020) Google Scholar Etain et al., 2013 B. Etain, M. Aas, O.A. Andreassen, S. Lorentzen, I. Dieset, S. Gard...
Experience-dependent pruning of local circuitry (Huttenlocher, 1979) and myelination of long-range connections (Paus et al., 2001) continue through early childhood and adolescence and has been observed with structural MRI (Casey et al., 2005; Lenroot and Giedd, 2006); these findings have since...
The answer to this question has to be a qualified yes. The nervous system is exceptionally complex and goes through a prolonged period of development characterised by cellular migration and differentiation, and synaptic pruning. The basic structures of the brain are formed in stages and the successf...
6. How does bipolar disorder fit into all of this? Is mania the answer to my “what is it like to have too many synapses?” question from point (3)? If so, why do some people go back and forth between that and depression?
Specific and well-organized cellular and molecular processes, including proliferation, migration, differentiation, myelination, and synaptic pruning, characterize the development of the nervous system. Any incident disrupting the sequence of developmental steps can lead to permanent or transient structural and...
cytokines cross the placenta and can act in fetal brain development, stimulating inflammatory mediators that damage the brain, affecting its epigenetics, and leading to harmful effects on its plasticity, the migration of precursors, synapse formation and pruning, thus impairing its cognitive functions [...
The Ca2+ response to VEGF is also sensitive to angiogenesis inhibitors, such as angiostatin and endostatin, which are necessary for vessel pruning and regression of selected vascular branches [12]. Angiostatin comprises of the first four-kringle domains of plasminogen, which is a quite abundant ...