delamanidtuberculosisBedaquiline and delamanid used to treat extensively drug-resistant tuberculosis are known to cause prolonged QTc. Two children with extensively drug-resistant tuberculosis were put on bedaquiline and delamanid and had prolonged QTc on the Bazett formula but normal QTc by the Fridericia...
If the patient has a prolonged QTc at baseline (>450 ms in men and >460 ms in women in the absence of interventricular conduction defects), it is important to try to avoid all QT-prolonging medications.47 Although this is not an absolute contraindication to starting QT-prolonging drugs, ...
Conclusion: ECG intervals are prolonged in approximately one third of all patients older than 90 years who present for routine medical care. The presence of coronary artery disease does not appear to have much impact on the ECG intervals. However, mean and median values for the PR, QRS, and...
If QTc prolonged on EKG, an alternate drug may be needed. Drug interaction: Conivaptan: could increase concentration ofCYP3A4 substrate. ESRD: Transdermal patch suggested to not be used with ESRD (MW 336; lipophilic; Vd 4 L/kg). CKD: Reduce dose by 50%; limited information on other ...
The prolonged pollutants and sunlight exposure played a crucial role in the severe deterioration of the mural. This example shows how the location, orientation, and exposure of these kinds of artworks are crucial for their durability. It has also been reported in the study of Pozo-Antonio et ...