First, because stimuli are perceived more intensely and/or remain at the forefront of attention for longer, we propose that this short-term habituation deficit can underlie aberrant salience, a process believed to be of central importance in the origin of positive psychotic symptoms. As a ...
In two cases of juvenile dermatomyositis, patients were positive for anti-MDA5 and anti-NXP2, respectively [54]. Another diagnosis was made in an adult male with cancer-associated dermatomyositis [55]. Only few cases of PSVD have been reported in relation to SjS [[56], [57], [58]], ...
The mechanism of memory remains one of the great unsolved problems of biology. Grappling with the question more than a hundred years ago, the German zoologist Richard Semon formulated the concept of the engram, lasting connections in the brain that resul
There is now strong evidence that hyper-dopaminergic activity underlies the positive psychotic symptoms of schizophrenia.1,2,3Dopaminergic abnormalities have a similarly proximate role in aberrant salience,4,5which Kapur and others have theorized is central to the genesis and understanding of positive ps...
GRIA1provides arguably the first clear link between a GWAS-positive finding in schizophrenia and a core psychological process at the heart of the disorder. Clearly, this remains a speculative notion and requires further critical evaluation using a range of approaches. The real value of rodent ...
Amcoff, K.; Joossens, M.; Pierik, M.J.; Jonkers, D.; Bohr, J.; Joossens, S.; Romberg-Camps, M.; Nyhlin, N.; Wickbom, A.; Rutgeerts, P.J.; et al. Concordance in Anti-OmpC and Anti-I2 Indicate the Influence of Genetic Predisposition: Results of a European Study of Twins...