The confines and routines of the office turned out to be its charm. They’re what allowed its occupants — in all their eccentricity — to shine. Bartleby’s office had a view of a wall and an air shaft; perhaps yours had a view of cubicles and more cubicles. Cramped quarters mean ...
The best designed, controlled, and reported study will be scientifically and ethically flawed if the model used does not in fact "do what it says on the label" and model the disease in question. In the case of OA animal models this issue can be particularly vexing. The variety of OA ...
It was only in the last century that CR was put to the test in more experimental settings. Clive McCay more formally kicked things off in the early 1930s (McCay et al., 1935), describing that CR without malnutrition prolongs mean (i.e., how long a population lives on average) and max...
Most drugs of abuse easily cross the placenta and can affect fetal brain development. In utero exposures to drugs thus can have long-lasting implications for brain structure and function. These effects on the developing nervous system, before homeostatic
In the last decades, wildlife diseases and the health status of animal populations have gained increasing attention from the scientific community as part of a One Health framework. Furthermore, the need for non-invasive sampling methods with a minimal im
‘animal advocate’ was through preventing and limiting suffering via the safeguarding of animal welfare. This may sound simple initially, but the analysis reveals how complex this can be in practice. As the following examples illustrate, this can mean drawing lines between ‘necessary’ and ‘...