Assessing the balance of risk and benefit of interval–prolonging When drugs that can prolong the QT interval are used, physicians should ensure that the potential benefits are clinically important and the risks are minimized. Specifically, they should determine whether the likely benefit justifies the...
Hope and love are popular themes of literature and art in many human societies. The human physiology of love and hope is less well understood. This review presents evidence that the lack of love and/or hope delays growth disturbs development and maturati
Cluster analysis of sputum granulocyte profiles has proposed eosinophil-rich sputum eosinophilia as a sign of a distinct eosinophil COPD phenotype [32], although the counts of eosinophils in airways do not seem to correlate strongly with disease progression as showed by GOLD staging [33]. However,...
When you have a change of grade, does that really mean anything? I don't know. Lastly, the fibrosis isn't the disease. We're trying to look at a reflection of a reflection of the thing that we're trying to measure. It's passed through all of these filters. Are we truly measuring...
12 The finding of multiple tender points on physical examination does not correlate with any specific muscle or soft tissue disease but, rather, reflects generalized heightened pain perception.11,13,14 Patients with FM are excessively tender at many musculoskeletal and nonmusculoskeletal sites. ...
The contrast agent consists of phospholipid-based microbubbles with a mean diameter on the order of 0.5–10 mm that encapsulate an inert gas, which when exposed to an US pulse, generate nonlinear resonances that allow enhanced representation of the vasculature. Microbubbles remain strictly ...
If a SARS-CoV-2 vaccine were to show efficacy, a priority would be to identify an in-vitro correlate or surrogate of protection.67 Other vaccine candidates could then be deemed efficacious and licensed if they induced similar levels of immune responses in non-inferiority studies, which would ci...
You may find this too, Dr Jain, when you're in clinic; you may do an MPN SAF on a patient one day and then do it again another day, and those scores don't correlate with each other at all. It may not have anything to do with the fact that the myelofibrosis is better or worse...
Autism, or autism spectrum disorders, is a neurodevelopmental condition characterized by limitations in social interaction, communication skills, and repetitive behaviors. Although motor disorders were previously considered marginal in autism, recent res
What relevance does this history have for the conceptual definition and measurement of the construct of depression today and going forward? This historical context provides the framing in which modern priorities, principles, and beliefs were first set, and understanding these prequels provides important...