Elderly populations may be uniquely susceptible to the effects of inflammation and CHIP as comorbidities and CHIP are more common in aging individuals. Several comorbidities with inflammatory components, such as ulcerative colitis, rheumatoid arthritis, and systemic sclerosis, have been linked to increased...
Given its effect on (stem) cell proliferation it does not come as a surprise that aberrant activation of the HH pathway can cause tumour formation. Basal cell carcinoma [84,85], medulloblastoma [86], meningiomas [87–89] and rhabdomyosarcoma [90] are all known to be caused by mutations in...