Small interfering RNA (siRNA) is also a type of short RNA molecule which regulates gene expression. In contrast to miRNA’s downregulating effect, siRNA can completely turn off protein production from a particular gene, thereby silencing the gene.Additional resources ...
What are introns, and how do they affect the processing of genetic information? What is the process by which information encoded in DNA directs the synthesis of proteins or, in some cases, RNAs that are not transl...
Metabolic reprogramming is a pivotal biological process in which cellular metabolic patterns change to meet the energy demands of increased cell growth and proliferation. In this review, we explore metabolic reprogramming and its impact on fibrotic disea
Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs, thereby globally affecting essentially any conceivable trait–stress responses, adaptive metabolic changes, virulence etc. The sRNAs...
But our discovery is a little bit different. We have found a new class of RNAs that have changed how we think about cancer detection. These are relatively small RNAs, and they don't actually code for any protein. So they'...
RNA was the first genetic molecule to arise about 4 billion years ago. It is hypothesized that later, RNA evolved into DNA. This hypothesis is based on the unique functions RNAs have. Unlike DNA, RNA can act as an enzyme and edit its genetic code, and therefore, it is believed that ...
Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs Article Open access 04 November 2023 Telomere damage induces internal loops that generate telomeric circles Article Open access 20 October 2020 References McClintock, B. The stability of broken ends ...
Determination of the ADME properties of nanoparticles requires specialised detection methods in different biological matrices (e.g. blood and organs). In this paper, the current knowledge on the kinetic properties of nanoparticles is reviewed. Moreover, knowledge gaps from a kinetic point of view (...
requiring meticulous optimization across multiple variables to establish an efficient system for each species. Second, the issue of off-target effects persists as a common challenge in CRISPR/Cas applications. Finally, selecting the most appropriate Cas proteins and single-guide RNAs (sgRNAs) is criti...
How do they differ? tRNA tRNAs (transfer RNAs) are sequences of RNAs that are critical in the synthesis of proteins by ribosomes. tRNAs will have one amino acid attached to them, which will be used in the synthesis of a polypeptide. There can only be one amino acid per tRNA, and sin...