What are cell cycle checkpoints? Where are they found in the cell cycle? What do they check for? What happens if cell cycle regulators don't function properly? What are the two major ubiquitin ligases that play a central role in the control of cell cycle progression?
What are the two major ubiquitin ligases that play a central role in the control of cell cycle progression? What cell cycle events are affected in a cell that produces mutated (non-functional) cohesion protein? Why? What parts of the cell are you able to id...
KCTD7 has been shown to directly interact with Cullin-3, a component of E3 ubiquitin-protein ligases that selectively tag proteins for degradation by the proteasome [260]. Staropoli et al. determined that the KCTD7 mutation originally described for CLN14 disease by them, which is not in the...
The identities of the important ubiquitin-protein ligases in skeletal muscle, and the ways in which they recognize substrates are still largely unknown. Recent in-vitro studies have suggested that one set of ubquitination enzymes, E2(14K) and E3(alpha), which are responsible for the 'N-end ...
a re-evaluation and optimization of already tested strategies such as intra-peritoneal therapy together with a deep investigation of the recently acquired knowledge on factors(e.g.,E3 ubiquitin ligases)and features[Cancer Stem Cells(CSCs)]contributing to drug resistance may provide useful insights to...
and TDP2 does not form covalent-linked intermediates [75,79,80]. TDP2 generates 5′-phosphate DNA ends, which can be directly processed by ligases. Homozygous mutations of the TDP2 gene were associated with spinocerebellar ataxia autosomal recessive 23, a disease characterized by intellectual disab...
Enzymes are actually classified into seven classes, namelyoxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, and translocases. The classification is related to the catalyzed reactions. This chapter presents the classification and nomenclature of these powerful biocatalyzers. ...
Photoreceptor-mediated control of E3 ubiquitin ligases such as CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1)/SUPPRESSOR OF PHYA-105 (SPA) determines the abundance of TFs acting downstream in light-signalling pathways (e.g. ELONGATED HYPOCOTYL 5 (HY5) and B-box proteins (BBX)) but also of MBW ...
Include the roles of helicases, transcription factors, primases, polymerases, ligases, and termination factors. What is transcription? Describe the process of transcription. Where does it occur? What enzyme(s) are involved? What is the product(s)? What role does DNA polymerase p...
Lyases catalyze the breaking of various chemical bonds by means other than hydrolysis and oxidation, helpful in glycolysis while ligases catalyze the joining of two molecules with the assistance of ATP, used in processes like DNA replication and repair. ...