This provides a key, mechanistic component of our present hypothesis that GluA1 dysfunction contributes to aberrant salience in schizophrenia; we further suggest that this is mediated via enhanced dopamine signalling. This proposal provides a plausible causal link between a robust schizophrenia risk gene...
There are several causes of an addictive personality. Genetics contributes approximately 40% to 70% of the influence on addictive personality. In...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tough ...
How people in long-term recovery (clinical and personal) in first-episode psychosis (schizophrenia and bipolar spectrum disorders) experience the mental health and welfare services they interact with is not frequently studied but has significant implications. We therefore aimed to explore which aspects ...
someone withschizophrenia, though most schizophrenics are law-abiding members of society, might be able to more easily claim that he is not guilty by reason of insanity. This might be particularly the case if the schizophrenic was not medicated or inadequately...
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009;460:748–52. PubMed Central Google Scholar Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe’er I, et al. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature. ...
A 2016 study provided evidence that vitamin B contributes to the complexity of depressive symptoms. Vitamin B1, B3, B6, B9, and B12 deficiencies have been linked to depression, researchers report. Vitamin B12 in particular is important, and has been associated with depression—and this vitamin is...
Working memory dysfunction is a core component of schizophrenia, which likely contributes substantially to the pervasive and profound cognitive deficits observed in patients with this illness. Developments in functional imaging have facilitated the investigation of the neural basis of these cognitive deficits...
Using known mouse models of ASD (e.g., MHFD), researchers can apply top-down approaches to study if the ASD model possesses microbial dysbiosis and if the altered microbiome contributes to the behavioral deficit. Bottom-up approaches (germ-free, gnotobiotic, antibiotic, and probiotics) allow ...
Not surprisingly, chromosomal sex also contributes to brain development in a hormone-independent manner. The four core genotype mice in which the testis-determining gene, Sry, has been removed from the Y chromosome and is now autosomal, are an interesting tool with which measured outcomes can ...
Just as every coin has its two sides, this failure also contributes to the understanding of the role of IDO1 inhibition and changes the clinical development program of inhibitors. Since the second half of 2018, seventeen new trials have been initiated and a large proportion of the clinical ...