Adenosine, a naturally occurring endogenous metabolite formed by the degradation of adenosine triphosphate (ATP), not only terminates but also helps define the mechanism of several arrhythmias discovered in 1929. ATP gets metabolized into adenosine after intravenous administration and is used to treat car...
What are the effects of heart rate on parasympathetic and sympathetic stimulation? How do antidepressants affect neurotransmitters? Is adenosine a neurotransmitter? Is norepinephrine a hormone or neurotransmitter? How do you increase the neurotransmitter GABA?
However, only one adenosine receptor-specific agent - the adenosine A(2A) receptor agonist regadenoson (Lexiscan; Astellas Pharma) - has so far gained approval from the US Food and Drug Administration (FDA). Here, we focus on the biology of adenosine signalling to ide...
What is Diclofenac sodium?Feb 11,2020 Diclofenac is a phenylacetic acid derivative belonging to the class of the non-selective non-steroidal anti-inflammatory drugs (NSAIDs). It exhibits analgesic, antipyretic and anti-inflammatory activity. Due to its poor solubility, the parenteral formulation of ...
Crystal meth addiction is defined as: Chronic use of methamphetamine, a Class A drug, and physical withdrawal symptoms upon cessation, Compulsive drug-seeking...
We discuss the complexity of adenosine signalling and drug effects over the continuum of specific disease courses, addressing the implications for the use of adenosine receptor-targeting agents. The adenosine receptor antagonist caffeine, which is commonly ingested, complicates the interpretation of clinica...
which is made through a multi-step process using recombinant DNA technology. Ecnoglutide also works in a slightly different way than other drugs in its class. It uses a molecule that helps cells communicate called cyclicadenosinemonophosphate (cAMP). cAMP boosts the signals that trigger insulin re...
The progression, recurrence and drug resistance of multiple myeloma are related to its inhibitory immune microenvironment. 2. Regulatory T cells play an important role in maintaining self-tolerance and regulating the overall immune response to infection or tumor cells, and can inhibit the activation, ...
Another common adjustment is add-on therapy to the existing regimen. This is often done without regard to the mode of action(s) that align with one of the drivers of hyperglycemia in a given patient. Ineffective therapy is costly in terms of drug acquisition cost as well as the potential ...
numerous studies have reported its toxicity risk. The European Commission has announced that beta-BETA-ASARONE has clear toxicity and is not recommended for clinical use alone as a therapeutic drug. The content of beta-BETA-ASARONE in marketed BETA-ASARONE drugs needs to be strictly controlled....