Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. Nat Commun. 2018;9:321. Article PubMed PubMed Central CAS Google Scholar Hoffmann TJ, Passarelli MN, Graff RE, Emami NC, Sakoda LC, Jorgenson E, et al. Genome-wide association study ...
Further investigations to delineate the causes and implications of non-classical HLA-I hyperexpression in type 1 diabetes pancreatic islets are, therefore, warranted.References Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance ...
The study of sexual dimorphism in psychiatric and neurodevelopmental disorders is challenging due to the complex interplay of diverse biological, psychological, and social factors. Males are more susceptible to neurodevelopmental disorders including inte
Diabetes has always been found as one of the main comorbidities associated with greater severity of symptoms of CHIK. Besides, but it is also associated with a higher rate of hospitalizations (RR: 1.39; 95% CI 1.06–1.84). Common causes of hospitalizations were: presence of unstable vital sign...
Additionally, it has been shown that CVDs are responsible for 45.45% of all-cause mortality in Iran [4], signaling a significant transition in the leading causes of death among Iranian people from diarrheal and infectious diseases to CVDs in the last few decades [5]. Coronary heart disease (...
While the exact causes and mechanisms are not fully understood, leading to the situation can only be managed but not cured. The microbiota with many residing on the skin and mucosal surfaces of the host body in a symbiotic relationship. In recent years, research has shown a significant link ...
Schizophrenia remains one of the leading causes of global disease burden in adults despite more than 50 years of drug development.1 Understanding its neurobiology is critical for future rational drug discovery.2,3 The dopamine hypothesis of schizophrenia was first proposed more than 30 years ago on...
As our screening revealed undiagnosed and untreated diabetes mellitus type II, we concluded that her mild liver dysfunction was probably caused by diabetes mellitus related non-alcoholic fatty liver disease. Diarrhea turned out to be a side effect of the medication she was using (pancreatin). ...
Causes of High TSH A high TSH level—above 4.5 mU/L—indicates an underactive thyroid, also known as hypothyroidism. This means your body is not producing enough thyroid hormone. A high TSH means different things depending on whether a person has known thyroid disease. ...
Several monogenic causes for PD have been identified (Blauwendraat et al. 2020). These findings have for example implicated dysfunction of mitophagy and autophagy in the pathogenesis of PD (Nguyen et al. 2019; Singleton and Hardy 2019). Mendelian PD is thought to potentially serve as a model...