Some drugs can also cause imbalances of electrolytes, which can be more dangerous than we think. As an example, executions in the United States call for a "lethal injection" that contains excess potassium because large amounts of potassium can stop the heart. ...
suggesting the reduction of Mmp1 activity and consequently diminishing ECM removal and increasing fibrosis.28 Elevated Timp1 expression can include MMPs inhibition,29,30 and two consequences directly related to the dystrophic process: intensify fibrosis and disturb regeneration, hampering cell migration by...
However, non-specific CPP-mediated cell penetration into normal tissues can lead to widespread organ distribution of the payloads, thereby reducing the therapeutic efficacy of the drug and at the same time increasing the drug-induced toxic effects. In view of these challenges, we present herein a...