It binds the cluster of differentiate (CD) 20 antigen which is overexpressed on tumor cells relative to mature human B-cells (and not expressed on immature human B-cells) leading to tumor cell death via antibody-dependent cellular phagocytosis (ADCP), antibody-dependent cellular cytotoxicity (ADCC...
can aggregate on PVM to form holes, destroying the replication region ofT. gondii76. Humans do not have IRG resistance systems77. Second, profilin is an actin-modifying protein that binds and activates TLR11 and TLR12, promotes IL-12 production, inducing NK cells to produce IFN-γ, which pl...
Galectin 9, for example, binds to the T cell immunoglobulin domain and mucin domain protein 3 (TIM3; also known as HAVCR2) on activated effector T cells and causes apoptosis, and at the same time it expands minimize tissue dthaemTagReeg. cell response44–46; It is possible that both ...
A TLR2 heterodimer, in combination with the TLR1, binds 19-kD mycobacterial lipoprotein, suggesting TLR2 is an adhesion molecule for M. tuberculosis [22]. A previous study suggests that Toll interleukin 1 receptor domain containing adaptor protein (TIRAP), an adaptor that mediates signals from ...
However, the S protein of SARS-CoV-2 binds to human ACE2 more weakly than that of SARS-CoV, which is coincident with the fact that SARS-CoV-2 causes less severe infection in patients than SARS-CoV [14]. SARS-CoV-2 can also form a novel short protein encoded by orf3b and a ...
Owing to the GAG-binding site within the amphipathic helix, Erns rather unspecifically binds to cell surfaces, and is thus able to act as IFN antagonist in cells of various species, e.g., caprine, ovine, canine, or human cells. Mutant proteins lacking 37 amino acid residues of the C-ter...
PIgA binds to the polymeric immunoglobulin receptor (pIgR) on the basal side of mucosal epithelial cells to form the pIgR/pIgA covalent complex, which is taken up by cells via endocytosis. Then, PIgR is cleaved by proteolytic enzymes, and the secretory fragments (SCs) are released and bind ...
(4) Heat resis- tance properties of shell material and nacre being the same, the cal- cium carbonate secreted by the pearl sac either in the aragonite or calcite form binds homogeneously and firmly with the calcium car- bonate layers of the shell beads with the help of conchiolin layer ...
can aggregate on PVM to form holes, destroying the replication region ofT. gondii76. Humans do not have IRG resistance systems77. Second, profilin is an actin-modifying protein that binds and activates TLR11 and TLR12, promotes IL-12 production, inducing NK cells to produce IFN-γ, which pl...
In addition to binding to membrane receptors, MT1 and MT2, melatonin also binds to calmodulin [108, 109]. Benitez-King and colleagues [110] reported data showing melatonin as an inhibitor of calcium-dependent calmodulin kinase II (CaMKII) protein phosphorylation. Inhibition of CAMKII activity was...