SGLT-2 Inhibitors: What The Nephrologist Needs To KnowAndrew J. King
SGLT-2 inhibitors,cardioprotective effects,NLRP3,neuroprotective effects,inflammasome Data availability:
Some of the greatest challenges in the management of diabetes and diabetes-related foot complications are lack of knowledge, patient awareness and poor adherence. It is vital that further education is provided for patients and HCPs on the understanding of DKA...
47,48]. SGLT-2 inhibitors exert a wide range of pleiotropic actions, some of which may prove as important future targets of therapy. SGLT-2 inhibitors reduce glycolysis, rebalance the coupling between glycolysis and oxidative
SGLT2 inhibitors such as dapagliflozin (Farxiga), canagliflozin (Invokana), empagliflozin (Jardiance), and ertugliflozin (Steglatro) GLP-1 receptor agonists such as lixisenatide (Adlyxin), exenatide (Bydureon, Byetta), semaglutide (Ozempic), albiglutide (Tanzeum), dulaglutide (Trulicity), and liraglutide...
SGLT2 inhibitors and the changing landscape for treatment of diabetes Ther Clin Risk Manag, 15 (2019), pp. 861-867 CrossrefView in ScopusGoogle Scholar 24 P. Kazemian, F.M. Shebl, N. McCann, R.P. Walensky, D.J. Wexler Evaluation of the cascade of diabetes care in the United States...
Oral agents especially metformin and SGLT2 inhibitors should likely be stopped. Biguanides, of which metformin is the only one in use for patients with T2DM and pre-diabetes, are known to increase lactic acid production in the gut, which is then normally cleared in liver. However, as ...
In people with T2D and established cardiovascular disease, the international guidelines for T2D recommend the use of GLP-1 RA or sodium glucose co-transporters 2 inhibitors (SGLT-2i) as first-line treatment (independent of HbA1c), based on multiple trials demonstrating their cardio-renal benefits...
Jardiance (empagliflozin) is a prescription drug used to manage blood glucose in people with type 2 diabetes. Jardiance belongs to a drug class called SGLT2 (sodium-glucose cotransporter) inhibitors. Common side effects include upper respiratory tract infection, increased cholesterol, joint pain, nause...
Sodium-glucose cotransporter-2 (SGLT2) inhibitors also have a uricosuric effect, probably induced by the inhibition of GLUT9b in the collecting duct50). On the other hand, pyrazinamide may induce hyperuricemia via the stimulation of URAT11). Regulation of Urate Transporter...