Nature Genetics47,8–12 (2015)Cite this article 73kAccesses 501Citations 75Altmetric Metrics Abstract The term 'super-enhancer' has been used to describe groups of putative enhancers in close genomic proximity with unusually high levels of Mediator binding, as measured by chromatin immunoprecipitation...
What are the steps of gene transcription that produce mRNA? What role do promoters play in transcription? Explain in detail. Describe transcription in your own words clearly but concisely enough that someone could visualize what is happening. ...
Despite the large number of genetic variants that have been associated with schizophrenia, few causal variants have been established, and most genetic associations have not imparted useful clinical applications [1]. Moreover, many of the genome-wide associated variants are not found in genes, possib...
What are proteins that bind to prokaryotic promoters to start transcription called? Which enzyme will be produced in a cell in which there is a nonsense mutation in the lac operon? Describe the process of transcription. Include the names of all molecules involved and what they do; location, en...
Chromatin is a complex of nuclear proteins with genomic DNA that not only allows densely packaging of the genome into the cell nucleus but also tightly controls the access to genes and their regulatory elements, such as promoters and enhancers. The latter process is regulated by methylation of ge...
Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine. The serotonin receptor type 3 is a pentameric ligand-gated ion channel regulating intestinal motility, nausea, and vomiting in humans. The HTR3B gene codes... MV Tzvetkov,C Meineke,E Oetjen...
Despite this differential expression,there exists a high degree of similarity among the cis-acting elements in the MMP promoters.The Activator Protein-1 (AP-1) site at approximately 70 bp upstream of the transcriptional start site has long been thought to play a dominant role in the ...
Y Joly,IN Feze - Current Pharmacogenomics and Personalized Medicinenomics) 被引量: 11发表: 2014年 How many genomes are enough? For identifying cis-regulatory regions such as enhancers and promoters, the genomes of three species that are roughly equidistant evolutionarily is the bar... TM Powledge...
What are proteins that bind to prokaryotic promoters to start transcription called? eukaryotic gene regulation: \\ Transcription factors are sometimes activated by phosphorylation as in the MAPK pathway. Explain how this links an extracellular hormone signal to eukaryotic gene transcription. Be specific....
Thepromoter, a DNA sequence that liesupstreamof the RNA coding region, serves as an indicator of where and in which direction transcription should proceed. The promoter is not actually transcribed; its role is purely regulatory. While promoters vary tremendously among eukaryotes, there are some comm...