While sequencing of the human genome surprised us with how many protein-coding genes there are, it did not fundamentally change our perspective on what a gene is. In contrast, the complex patterns of dispersed regulation and pervasive transcription uncovered by the ENCODE project, together with non...
MG-132 subunit PI31 antibody Among the class 1 PI3Ks in two grasses, class 1A PI3Ks are heterodimers composed of catalytic pllO subunits (a, 13, S isoforms), which are structurally related to regulatory subunit (can be p85a, p55a, p50a, p85P or p55Y). Class IB has a family member...
To determine the contribution of Ras gene mutations to this aberration, we... CB Knobbe,J Reifenberger,G Reifenberger - 《Acta Neuropathologica》 被引量: 210发表: 2004年 Comparative analysis of theNF2, TP53, PTEN, KRAS, NRAS andHRAS genes in sporadic and radiation-induced human meningiomas ...
We applied SMRT-Cappable Seq to the best annotated prokaryotic genome, E.coli, and demonstrated that 34% of operons in E.coli are longer than the known annotations by at least one additional gene(s). Phasing operons also enabled to observe operon variants and an granularity in the operon ...
The Nitric oxide synthase (NOS) gene, present on the human chromosome 17q11.2–12, transcribes NOS enzymes that cause the oxidative deamination of amino acid L-arginine to form nitric oxide (NO). There are three isoforms of NOS enzymes: neuronal nitric oxide synthase (nNOS), endothelial nitri...
Gene Expression Regulation, EnzymologicBinding SitesPhosphoinositide-specific phospholipase C (PI-PLC) plays a pivotal role in regulation of intracellular signal transduction from various receptor molecules. More than 10 members of human PI-PLC isoforms have been identified and classified into three ...
aIn this study, we found that different types of testicular cells (i.e. somatic and germ cells) produced different transcript isoforms in the Adam21 (also known as Adam31) gene. 在这项研究中,我们发现那不同 testicular 细胞的输入 ( 即 somatic 和微生物细胞 ) 生产不同抄本在 Adam21 中同...
How- ever, recent studies indicate that EGF may have a function in aiding RGC survival; it has been found that Nell2, an EGF-re- lated gene, supports RGC survival after optic nerve injury[174]. Vascular endothelial growth factor (VEGF) exists as several isoforms, VEGF-A, -B, -C, and...
Women at high altitude are at increased risk of pregnancy complications, such as IUGR, preeclampsia and gestational diabetes (GDM), and may experience higher rates of intrauterine, neonatal and maternal mortality [13]. Indeed, similarities in gene expression profile have been demonstrated between ...
(B)Arraystar LncRNA Microarray transcript-specific probes unambiguously and accurately detect and quantify transcript isoforms BCL-XL, BCL-XS, and ENST412972 having distinct oncogenic functions. The “Gene-specific” probes not designed for lncRNA isoforms cannot make such distinction. The arrows ...