Targeting epigenetic regulators for cancer therapy Human gene expression patterns are controlled and coordinated by the activity of a diverse array of epigenetic regulators, including histone methyltransfer... S Wee,D Dhanak,H Li,... - 《Annals of the New York Academy of Sciences》 被引量: 92...
Other approaches such as epigenetic study suggested that women with higher blood DNA methylation levels than expected based on her chronological have an increased risk of EM [2]. The current understanding of the genetics underlying menopausal traits, pathways, and clinical relevance is limited. Multi...
When a pregnant woman and the generations that produced her are understood through epigenetic studies as the environmental contexts of another person, responsibility has the potential to be reimagined as existing in relations and configurations that move beyond individualized understandings of personhood. ...
• Despite abundant evidence that most kinds of tumor cells carry so-called epigenetic changes, scientists haven’t yet worked out exactly whether such glitches are a cause or a consequence of disease.[13] • The clarification of the cause-and-effect relationship of nuclear organization and th...
reported a complex association between VDR gene methylation and the TaqI genotype, which highlighted the need to consider how both genetic and epigenetic variation associates with tuberculosis [62]. The variation in VDR gene methylation, and its impact on VDR expression and tuberculosis susceptibility ...
摘要: Parental nutrition influences the health of subsequent generations through epigenetic changes in germ cells [Also see Research Article by Radford et al.] Authors: Martha Susiarjo, Marisa S. Bartolomei关键词: Spermatozoa Animals Fetal Nutrition Disorders Prenatal Exposure Delayed Effects DNA ...
Taken together, prenatal asthma protection afforded by a farming environment might be mediated by trans-placental transfer of cytokines and subsequent epigenetic events, e.g., in fetal immune cells. Further studies are needed to draw a com- prehensive picture of these events in animal models as ...
(and absence of exogenous infections) are still unknown, especially considering that all AMPs areimd/relish-dependent in this tissue [83]. This finely tuned, selective response may involve specific modulation of promoters that regulate expression of AMP encoding genes, or epigenetic modifications such...
progress has been slow because multiple genes of small effect size are likely to influence anxiety. This article explains how the hunt for genes involved in anxiety is likely to benefit from genetically sensitive research, which examines the co-occurrence of symptoms; includes measures of the enviro...
Moreover, women perceive asthma more sensitively and report more respiratory discomfort than men, even if the symptoms and objective clinical measures are similar [222]. 5.6. Genetically Conditioned Factors 5.6.1. Sex-Specific Genes, Epigenetic Changes, and miRNA The influences of the genetic ...