New biomarkers are being discovered all the time. Research on biomarkers can reveal ways to tell if people have taken various drugs, been exposed to dangerous toxins or diseases, and even what part of the world someone has been spending time in. Specific biomarkers are also sometimes used to ...
Publication » 9 What is normal? Validation of cancer biomarkers using saliva from a control group.doi:10.1016/S0266-4356(10)60010-1A. M. MatthewsH. KaurL. LiloglouR. ShawJ. RiskElsevier LtdBritish Journal of Oral & Maxillofacial Surgery...
Predictive biomarkers are used to identify those patients who are likely to have a positive clinical outcome in response to a given treatment. Thus, with the help of predictive biomarkers, it is possible to give a particular therapy to the patients for which it is most likely to be effective....
SCLC; biomarkers; programmed death ligand 1; tumour mutational burden; tumour microenvironment; serum anti-neuronal nuclear antibodies; SCLC-I subtype1. Introduction Small-cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy that exhibits a rapid doubling time, a high growth fraction, ...
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In general, clinical efficacy studies aren’t required if there’s sound PK and PD biomarker data. PK similarity alone may be sufficient to support a biosimilar application. However, drug developers commonly use PD biosimilarity when there are sensitive exposure-dependent changes in biomarkers. For...
One of the first things to understand is that not all lung cancers are the same. Comprehensive biomarker testing can identify specific mutations (also known as genetic “drivers”) in your cancer called biomarkers. These mutations cause cancer to grow and spread in different ways...
” Cancer Epidemiol Biomarkers Prev; 22(2); 286–94. ©2012 Or, you can take a look at tons of research that has been done on the cancer preventative benefits of eating vegetables and the cancer correlations with diets high in fat, especially animal fat. (See www.PCRM.com The ...
Search all BMC articles Search Breast Cancer Research Home About Articles Submission Guidelines Submit manuscript Consistency, now what? Download PDF Download PDF Editorial Open access Published: 21 July 2017 Consistency, now what? Mary Beth Terry1,2 ...
The emergence of new novel therapeutic agents which directly target molecules that are uniquely or abnormally expressed in cancer cells (molecular targeted therapy, MTT) has changed dramatically the treatment of cancer in recent years. The clinical benefit associated with these agents is typically limite...