Tregs are a subset of mature T cells with regulatory function, which play an important role in maintaining self-tolerance and regulating the overall immune response to infection or tumor cells. Tregs can inhibit the activation, proliferation and function of immune cells such as CD4+and CD8+T cel...
Biological activities of thujone have now been justified by modern instruments, pharmacological and clinical investigations. The mechanism of neurotoxicity of thujones has been widely investigated in animals, cultured neuronal cells and expressed receptors. Thujones are modulators of the GABA-gated chloride...
phagocytosis. Thus, pDC are weak stimulators of T cells. On the other hand, all conventional DC are MHC class II+ and the majority are CD8αα+. Similar to the minority population of CD8+DC in the spleen and lymph node, this population in the thymus is DEC-205+(CD205) and CD11b...
We will briefly summarize the biological drugs that are in phase I trials: mosunetuzumab, itolizumab, CM313, and DS-7011a. Mosunetuzumab, a CD20/CD3 bispecific antibody, engages T cells and redirects them to attack CD20+ B-cells [121]. It has been recently approved in Europe for the...