To study howVibriodevelops resistance, we chose a strain that is tolerant to a class of antibioticscalled beta-lactams. Beta-lactams are the cannonball sent to destroy the bacteria�s fortress, andVibrioadapts by activating two genes that temporarily remove its cell wall. I witnessed this pheno...
BLs are still the most commonly prescribed and used antibiotics in children. Viral infections are very often in children and they can provoke skin rashes which are difficult to differentiate from DHRs. The majority of children are incorrectly labeled as "allergic". Therefore, allergy to BLs in ...
Some common Actinobacteria derived antibiotics are tetracyclines, cephamycins, macrolides (like streptomycin, erythromycins, gentamicin, etc.) quinolones, chloramphenicol, some aminoglycosides, some β- lactams, rapamycin, etc. Antifungal compounds like amphotericin, daryamides, etc., an antiparasitic compoun...
plasmids has a limit as the latter belong to a wide range of incompatibility groups, each of which may employ different strategies for host colonization and establishment. Proteins that are directly involved in MPF and conjugative DNA processing are not discussed here as they are reviewed in detail...
The use of noncarbapenem β-lactams for the treatment of extended-spectrum β-lactamase infections. Clin Inf Dis. 2017;64(7):972-980. doi: 10.1093/cid/cix034. Bouxom H, Fournier D, Bouiller K, Hocquet D, Bertrand X. Which non-carbapenem antibiotics are active against extended-spectrum ...
pneumoniae, including strains resistant to beta-lactams and colistin, an antibiotic regarded as last-resort therapy. Enterobacteriaceae have been highlighted by the World Health Organization as priority pathogens, against which new antibiotics are urgently needed. This project has been awarded a grant ...
beta-lactamase inhibitor tazobactam has potent activity againstP. aeruginosa, including various MDR types [80]. Another alternative for the treatment of MDR, XDR and PDRPseudomonasssp. is the use of intra-tracheal antibiotics (ITA), consisting mainly of aminoglycosides and polymyxins, with encouraging...
Penicillin-based antibioticsremain the first line for the treatment of odontogenic infections. Metronidazole is effective against anaerobic bacteria. The antibiotic doses recommended in the SDCEP's guidance are based on the doses recommended by the British National Formulary (BNF)13(Table 2). ...
23、ing must be adjusted “front -loaded” dosing and especially applies to hydrophilic drugs whose Vd dramatically increases in this scenario Vd of hydrophilic antibiotics is increased in obese patients due to the increased interstitial fluid, connective tissue, and muscle mass also present in obesit...
The risk of hospitalization was lower in patients treated with antibiotics supposed to be effective against C. burnetii (doxycycline and fluoroquinolones) compared to patients treated with beta-lactams or azithromycin; the lowest risk of hospitalization was observed in patients treated with doxycycline ...