Though MBI is typically considered in the context of liver enzymes (particularly CYPs), this concept could theoretically be extended to other metabolizing enzymes. For example, neutrophil myeloperoxidase (MPO) has been cited as a key enzyme involved in metabolic activation of multiple drugs including ...
proteins identified in genetic asso- ciation studies, (ii) the position of the hapten modification is important for stimulating T-cells, and (iii) that haptens and the hapten concept is relevant (alongside the PI concept) for adverse reactions associated with expression of a specific HLA allele...